Evolutionary History of DNA Methylation Related Genes in Bivalvia: New Insights From Mytilus galloprovincialis

DNA methylation is an essential epigenetic mechanism influencing gene expression in all organisms. In metazoans, the pattern of changes during embryogenesis and adult life. Consequently, differentiated cells develop a stable unique that finely regulates mRNA transcription development determines tissue-specific expression. Currently, remains poorly investigated mollusks completely unexplored Mytilus galloprovincialis . To shed light on this process ecologically economically important bivalve, we screened its genome, detecting sequences homologous to methyltransferases (DNMTs), methyl-CpG-binding domain (MBD) proteins Ten-eleven translocation methylcytosine dioxygenase (TET) previously described other We characterized architecture protein domains mussel studied their phylogenetic relationships with ortholog from bivalve species. then comparatively levels across different tissues bivalves, using published transcriptome datasets. This study provides first insights regulators M. , which may provide fundamental information better understand complex role played by regulating genome activity bivalves.